Li, W, Chen, JY, Sun, S, Sparks, RP, Pantano, L, Rahman, R, Moran, SP, Pondick, JV, Kirchner, R, Wrobel, D, Bieler, M, Ho Sui, SJ, Doerner, JF, Jörg F. Rippmann, JF, Mullen, AC (2021). Nanchangmycin regulates FYN, FAK and ERK to control the fibrotic activity of hepatic stellate cells. bioRxiv


Daneshvar, K, Ardehali, MB, Klein, IA, Fu-Kai, H, Kratkiewicz, AJ, Mahpour, A, Cancielliere, SOL, Zhou, C, Cook, BM, Li­­, W, Pondick, JV, Gupta, SK, Moran, SP, Young, RA, Kingston, RE, Mullen, AC. (2020). lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. Nature Cell Biology. 22, 1211-1222. Pubmed


Alsamman, S., Christenson, S.A., Yu, A., Ayad, N.M.E., Mooring, M.S., Segel, J.M., Hu, J K-S, Schaub, J.R., Ho, S.S., Rao V., Marlow, M.M., Turner, S.M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D.D.S, Ma, H-Y., Duwaerts, C.C., Espanol-Suner, R., Wei, L., Newcomb ,B., Mileva, I., Canals, D.,, Hannun, Y.A., Chung, R.T., Mattis, A.N., Fuchs, B.C., Tager, A.M., Yimlamai, D., Weaver, V.M., Mullen, A.C., Sheppard, D., Chen, J.Y. (2020) Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Science Translational. 12, eaay8798. Pubmed


Mahpour, A. and Mullen, A.C. (2020) Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy. JHEP Reports. 3(1):100177. (Review). Pubmed


Chan Z, Molinie B, Daneshvar K., Pondick JV, Wang J, Wittenberghe NO, Xing Y, Giallourakis CC, Mullen AC. (2017). Genome-wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell Reports. 20, 2262-2276.  Pubmed


Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC. (2017). Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Scientific Reports. 7, 44867.  Pubmed


Mullen AC and Wrana JL. (2017). TGF-beta family signaling in embryonic and somatic stem cell renewal and differentiation.  Cold Spring Harbor Perspectives in Biology. Jan 20;:a022186–33.  Pubmed


Daneshvar K, Pondick JV, Kim, BM, Zhou C, York SR, Macklin JA, Abualteen A, Bo T, Sigova, AA, Marcho, C, Tremblay, KD, Mager J, Choi MY, Mullen AC. (2016). DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Reports. 17, 353-365.  Pubmed


Zhou C, York SR, Chen JY, Pondick J, Motola, D, Chung, RA, Mullen AC. (2016). Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome Medicine. 8, 31. PMCID PMC4804564.  Pubmed


Molinie B, Wang J, Lim K-S, Hillebrand R, ‎ Lu Z-X, Van Wittenberghe N, Howard BD, Daneshvar K, Mullen AC, Dedon P, Xing Y, Giallourakis CC. (2016). m6A level and isoform characterization sequencing (m6A-LAIC-seq) reveals the census and complexity of the m6A epitranscriptome. Nat Methods.13, 692-8.  Pubmed


Batista, PJ, Molinie, B, Wang, J, Qu, K, Zhang, J, Li, L, Bouley, D M, Lujan, E, Haddad, B, Daneshvar, K, Carter, AC, Flynn, RA, Zhou, C, Lim, K-S, Dedon, P, Wernig, M, Mullen, AC, Xing, Y, Giallourakis, CC, Chang, HY. (2014). m6A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 15, 707-719.


Sigova, AA, Mullen, AC *, Moline, B, Gupta, S, Orlando, DA, Guenther, MG, Alamada, AE, Lin C, Sharp, PA, Giallourakis, CC, Young, RA (2013). Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.  Proceedings of the National Academy of Sciences USA 110, 2876-81. * co-first author.  Pubmed


Mullen, AC, Orlando, DA, Newman, JJ, Loven, J, Kumar, RM, Bilodeau, ., Reddy, J, Guenther, MG, DeKoter, RP, and Young, RA (2011). Master transcription factors determine cell-type-specific responses to TGF-beta signaling. Cell 147, 565-576.  Pubmed


Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., and Reiner, S. L. (2003). Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science 302, 1041-1043.


Mullen, A. C., Hutchins, A. S., High, F. A., Lee, H. W., Sykes, K. J., Chodosh, L. A., and Reiner, S. L. (2002). Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction. Nature Immunology 3, 652-658.


Hutchins, A. S., Mullen, A. C., Lee, H. W., Sykes, K. J., High, F. A., Hendrich, B. D., Bird, A. P., and Reiner, S. L. (2002). Gene silencing quantitatively controls the function of a developmental trans-activator. Mol Cell 10, 81-91.


Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L., Cereb, N., Yao, T. P., Yang, S. Y., and Reiner, S. L. (2001). Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292, 1907-1910.


Mullen, A. C., Hutchins, A. S., Villarino, A. V., Lee, H. W., High, F. A., Cereb, N., Yang, S. Y., Hua, X., and Reiner, S. L. (2001). Cell cycle controlling the silencing and functioning of mammalian activators. Curr Biol 11, 1695-1699.


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